Long COVID Blood-Brain Barrier Disruption
In a recent study published on Research Square* preprint servers, researchers examined the destruction of the blood-brain barrier (BBB) due to cognitive impairment associated with ongoing coronavirus disease (COVID). background
Studies have demonstrated the microvascular injury observed in the brains of deceased patients with acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including thinning of the laminae of endothelial cells in the olfactory bulb and leakage of fibrinogen. BBB-related changes and responses after exposure to SARS-CoV-2 have also been studied. In addition, evidence suggests that the SARS-CoV-2 spike protein can effectively cross the rodent BBB, which can lead to cognitive changes as well as inflammation. However, cerebrovascular pathology in patients and related mechanisms require further research, particularly in long-standing COVID patients. The impact of COVID-19 on BBB changes also remains to be explored.
In this study, researchers assessed the neurobiological effects of COVID-19 in patients diagnosed with acute SARS-CoV-2 infection … Read the restRead More