From digital therapeutics to personalized mental health solutions: Pear Therapeutics expands platform via partnerships with Empatica, etectRx, KeyWise, and Winterlight

Pear Therapeutics Expands Platform with Digital Biomarkers, Machine Learning Algorithms and Sensor-Based Technologies (press release):

Pear Therapeutics, Inc. announced today that it has entered into agreements with multiple technology companies, including Empatica Inc., etectRx, Inc., and KeyWise, Inc. The new technologies complement the voice-based biomarkers previously licensed from Winterlight Labs. These new agreements bolster Pear’s Prescription Digital Therapeutics (PDT) platform, by adding to its library of digital biomarkers, machine learning algorithms, sensor-based technologies, and digital therapeutics.

The newly licensed technologies enable the building of a comprehensive product offering for remote sensing of patient physiology. Pear’s physiologic sensing portfolio could allow for real-time personalization of digital therapeutic content and pharmaceutical dosing, creating the opportunity for enhanced patient outcomes across a wide range of disease states.

  • Pear is collaborating with Empatica, a pioneer in developing medical wearables and digital biomarkers, to explore using wearable sensors to evaluate withdrawal symptoms in patients with substance use disorder (SUD), opioid use disorder (OUD) and alcohol use disorder (AUD). Empatica’s smartwatches are FDA cleared and CE-marked, and are designed to track heart rate, fine locomotor behaviors, skin temperature, and skin conductance to quantify autonomic nervous system response.

  • Pear is collaborating with etectRx, Inc., an innovator in medication adherence technology, to explore the development of digital therapeutics combined with digital pills. etectRx’s ID-Cap™ System, a digital pill system that is FDA cleared as an ingestible event marker, is designed to guide digital, patient-centric, and value-based therapeutic interventions to enhance medication adherence and improve patient outcomes.

  • Pear has licensed an artificial intelligence-enabled keystroke detection algorithm from KeyWise, a developer of science-backed digital biomarkers through smartphone keyboard interactions. Pear intends to build capabilities to track and produce individualized mental health metrics with natural language processing in PDTs. Pear licensed the technology to develop and clinically validate digital biomarkers across a variety of conditions, including depression, bipolar disorder, schizophrenia, substance use disorder, opioid use disorder, insomnia and pain.

  • In 2020, Pear licensed from Winterlight Labs machine learning-based voice digital biomarkers that analyze and assess cognitive health. Pear licensed the technology to develop and clinically validate digital biomarkers for a variety of diseases, including Alzheimer’s disease, depression, insomnia, schizophrenia, opioid use disorder, and substance use disorder.

News in Context:

  • Pear Therapeutics raises $80M; finds cost savings of $2,150 per patient with opioid use disorder
  • The FDA clears Somryst, Pear’s digital therapeutic to treat chronic insomnia
  • Novartis dissolves agreement to market Pear Therapeutics’ prescription digital therapeutics for substance/ opioid abuse
  • Ten neurotechnologies about to transform brain enhancement & health
  • Five reasons the future of brain enhancement is digital, pervasive and (hopefully) bright
Rethinking and Retooling Brain Health and Mental Health from SharpBrains

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